What is PD ISO/TR 21624 about?
PD ISO/TR 21624 discusses in vitro studies of airborne nano‐objects and their aggregates and agglomerates (NOAA) for nanotechnologies. PD ISO/TR 21624 provides guidance practices regarding the systems available for exposure and assessment of nano-objects and their aggregates and agglomerates (NOAA) for in vitro air exposure studies. PD ISO/TR 21624 provides an overview of the various exposure systems and in vitro cell systems used to perform in vitro studies that simulate an inhalation toxicology study design. PD ISO/TR 21624 helps in delivering pharmaceuticals to patients with lung or airway diseases and is also a leading route of unintended exposure during manufacturing, handling, or use of chemical and agrochemicals.
Who is PD ISO/TR 21624 for?
PD ISO/TR 21624 on airborne nano‐objects and their aggregates and agglomerates (NOAA) is useful for:
- Nanotechnologies developers and manufacturers
- In vitro diagnostic centres
- Regulatory authorities
Why should you use PD ISO/TR 21624?
Inhalation is one of the prominent routes by which humans can come in contact with natural, unintended, and engineered nano-objects and their aggregates and agglomerates (NOAA). Due to the physiological, biochemical, and anatomical differences between humans and animals, considerable time, cost, and animal numbers are required to conduct in vivo toxicity tests. There is much interest in developing in vitro strategies that are based on human cells and mechanisms of toxicity.
PD ISO/TR 21624 provides practice guidance on considerations for in vitro systems for assessing inhalation exposure to NOAA, Considerations for characterizing NOAA tested in vitro studies of airborne nanomaterials, and choice of the appropriate dose and dose metrics for in vitro studies of airborne nano‐objects and their aggregates and agglomerates (NOAA). This helps in properly assessing the inhalation toxicity of NOAA.
