What is ISO/TS 22693 about?
ISO/TS 22693 discusses genomics informatics. ISO/TS 22693 focuses on structured clinical gene fusion reports in electronic health records.
ISO/TS 22693 specifies data elements and their required metadata to implement a structured clinical gene fusion report whose data are generated by next-generation sequencing technologies.
ISO/TS 22693 describes:
- Reporting guidelines for RNA sequencing approaches
- Required data fields and optional data fields and their metadata
- Optional data fields and their metadata
ISO/TS 22693 covers fusion genes from human specimens for clinical practices and research.
Note 1: ISO/TS 22693 does not cover Sanger sequencing methods and fusion genes detection using DNA sequencing methods.
Note 2: ISO/TS 22693 does not cover basic research and other scientific areas.
Note 3: ISO/TS 22693 does not cover any other biological species and any other structural variations.
Note 4: ISO/TS 22693 only defines the data elements and their metadata for the structured clinical sequencing report. Therefore, the layout can be designed based on the institutional decision if all elements are included as per this document.
Who is ISO/TS 22693 for?
ISO/TS 22693 on structured clinical gene fusion report is relevant to:
- Health care workers
- Medical records technician
- Bioinformaticians
- Research laboratories
- Medical institution
Why should you use ISO/TS 22693?
Due to the rapid advancement in next-generation technologies, clinical sequencing is used to realize precision medicine.
An inexpensive NGS (Next-generation sequencing) method is actively used in clinical practices due to its potential of detecting many genes at once. There are both DNA-based and RNA-based methods used for detecting fusion using NGS. RNA-based is more accurate in terms of detection sensitivity due to which they need for developing other clinical RNA sequencing has increased. Technological advancements have continually shaped the way that RNA-based (transcriptome) measurements are used in the clinic.
ISO/TS 22693 aids in developing RNA sequencing or whole transcriptome sequencing reports and a structured clinical report for taking clinical decisions.
ISO/TS 22693 provides information that helps in creating a structured gene fusion report for analysis by the researcher.
An efficient structured clinical gene fusion report can enhance the quality of clinical decisions taken regarding gene fusion.
